Hypothalamus gonadotrophin-releasing hormone neuron differentiation

Across TCGA cell cohorts, RNA activity of the Hypothalamus gonadotrophin-releasing hormone neuron differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NXF1, SLC39A13, and KIT, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NXF1 grouped by Hypothalamus gonadotrophin-releasing hormone neuron differentiation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NXF1 →	-0.485	-0.160	.002	.002	2	5
UPPER_AERODIGESTIVE_TRACT	SLC39A13 →	-0.480	-0.315	.009	.004	3	4
LUNG_NSCLC_LUAD	KIT →	-0.136	-0.185	.002	.001	3	4
PANCREAS	ARL15 →	+0.141	+0.161	.001	<.001	3	4
SOFT_TISSUE	NUDT1 →	-0.288	-0.282	<.001	<.001	3	3
SOFT_TISSUE	MFSD10 →	-0.209	-0.245	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NXF1 by Hypothalamus gonadotrophin-releasing hormone neuron differentiation activity — BREAST

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