Forebrain cell migration

Across TCGA cell cohorts, RNA activity of the Forebrain cell migration pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EGFR, GPD1L, and RHOBTB3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Forebrain cell migration activity versus EGFR in SOFT_TISSUE (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	EGFR →	+3.965	+0.517	.001	.006	3	7
BREAST	GPD1L →	-1.653	-0.333	<.001	.001	3	7
SOFT_TISSUE	RHOBTB3 →	+3.650	+0.399	<.001	.006	2	8
PANCREAS	MRPS25 →	-0.987	-0.303	.001	.001	3	7
STOMACH	LAMP2 →	+1.454	+0.689	.003	<.001	3	7
BREAST	LOXL2 →	+2.502	+0.184	.002	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021885 vs EGFR — SOFT_TISSUE

Explore this scatter interactively →