Forebrain neuron development

Across TCGA patient cohorts, RNA activity of the Forebrain neuron development pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RNASE1, SVEP1, and VIM_S73, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Forebrain neuron development activity versus RNASE1 in LUAD (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNASE1 →	+0.454	+0.052	.001	<.001	3	6
OV	SVEP1 →	+0.585	+0.047	.003	.002	3	5
PDAC	VIM_S73 →	+0.503	+0.058	.004	<.001	3	5
UCEC	RSL1D1_S427 →	-0.948	-0.080	<.001	<.001	3	5
UCEC	SRPK1_S311 →	-0.405	-0.078	.001	<.001	3	5
PDAC	TIMP2 →	+0.490	+0.054	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021884 vs RNASE1 — LUAD

Explore this scatter interactively →