Forebrain neuron differentiation

Across TCGA patient cohorts, RNA activity of the Forebrain neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLXDC1, INHBB, and LINC02266, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Forebrain neuron differentiation activity versus PLXDC1 in OV (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PLXDC1 →	+0.697	+0.772	.004	.003	3	5
LSCC	INHBB →	+1.092	+0.286	<.001	<.001	3	5
CCRCC	LINC02266 →	+0.459	+0.581	<.001	<.001	3	4
COAD	LDLRAD3 →	+0.687	+0.310	.007	.006	3	4
BRCA	COL1A1 →	+1.137	+0.351	.001	.001	3	4
CCRCC	JAM2 →	+0.987	+0.599	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021879 vs PLXDC1 — OV

Explore this scatter interactively →