Forebrain neuron differentiation

Across TCGA cell cohorts, RNA activity of the Forebrain neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DIAPH1, FAM166A, and LMAN1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Forebrain neuron differentiation activity versus DIAPH1 in BLOOD_Leukemia (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DIAPH1 →	+0.772	+0.698	<.001	.005	3	3
URINARY_TRACT	FAM166A →	-0.304	-0.348	.008	.009	3	3
CNS	LMAN1 →	-0.626	-0.208	.002	.001	3	3
PANCREAS	PSMG1 →	-0.758	-0.240	.002	<.001	3	3
PANCREAS	IRF9 →	+1.439	+0.226	.004	.002	3	3
UPPER_AERODIGESTIVE_TRACT	MYLK3 →	+0.146	+0.160	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021879 vs DIAPH1 — BLOOD_Leukemia

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