Forebrain generation of neurons

Across TCGA cell cohorts, RNA activity of the Forebrain generation of neurons pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM126B, RREB1, and FAM166A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Forebrain generation of neurons activity versus TMEM126B in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TMEM126B →	-1.034	-0.184	.008	.004	3	4
URINARY_TRACT	RREB1 →	+0.493	+0.333	.004	<.001	3	4
URINARY_TRACT	FAM166A →	-0.380	-0.448	.003	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	B9D1 →	-0.918	-0.224	.003	.003	3	3
UPPER_AERODIGESTIVE_TRACT	RPS6 →	-1.178	-0.195	.004	.009	3	3
UPPER_AERODIGESTIVE_TRACT	RACK1 →	-0.971	-0.165	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021872 vs TMEM126B — UPPER_AERODIGESTIVE_TRACT

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