Forebrain ventricular zone progenitor cell division

Across TCGA patient cohorts, RNA activity of the Forebrain ventricular zone progenitor cell division pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIM3, ZC3HC1_S24, and AHNAK, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Forebrain ventricular zone progenitor cell division activity versus TRIM3 in BRCA (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRIM3 →	+0.355	+0.071	<.001	.008	3	7
LUAD	ZC3HC1_S24 →	-0.798	-0.142	.001	.001	3	7
BRCA	AHNAK →	+0.384	+0.118	<.001	<.001	3	7
PDAC	NCL_S67 →	-0.620	-0.078	.006	.004	3	7
BRCA	NUP93 →	-0.206	-0.110	<.001	<.001	3	7
CCRCC	PHF3_S1133 →	-0.292	-0.129	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021869 vs TRIM3 — BRCA

Explore this scatter interactively →