Forebrain ventricular zone progenitor cell division

Across TCGA cell cohorts, RNA activity of the Forebrain ventricular zone progenitor cell division pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP2R1, NPIPA5, and ATF2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYP2R1 grouped by Forebrain ventricular zone progenitor cell division-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CYP2R1 →	+0.678	+1.257	<.001	<.001	3	4
BLOOD_Lymphoma	NPIPA5 →	-2.906	-1.388	.003	<.001	3	4
SOFT_TISSUE	ATF2 →	+0.790	+1.365	.003	.001	3	3
SOFT_TISSUE	MAML1 →	+0.458	+1.365	.007	.001	3	3
SOFT_TISSUE	HADHA →	+0.593	+1.292	.009	.003	3	3
LUNG_NSCLC_LUSC	POM121L2 →	+0.062	+1.565	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYP2R1 by Forebrain ventricular zone progenitor cell division activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →