Forebrain ventricular zone progenitor cell division

Across TCGA cell cohorts, RNA activity of the Forebrain ventricular zone progenitor cell division pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJB6, SIK2, and SLC6A19, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNAJB6 grouped by Forebrain ventricular zone progenitor cell division-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	DNAJB6 →	-0.358	-1.582	.003	<.001	3	4
SOFT_TISSUE	SIK2 →	-0.165	-1.178	<.001	<.001	3	4
SOFT_TISSUE	SLC6A19 →	+0.395	+1.374	.006	.001	3	4
SOFT_TISSUE	CEP43 →	+0.199	+1.156	.009	.005	2	5
UPPER_AERODIGESTIVE_TRACT	RNF133 →	+0.260	+1.669	.003	<.001	3	4
LIVER	NSUN2 →	+0.153	+1.726	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNAJB6 by Forebrain ventricular zone progenitor cell division activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →