Pyramidal neuron development

Across TCGA patient cohorts, RNA activity of the Pyramidal neuron development pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CALML4, GALE, and PMM2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyramidal neuron development activity versus CALML4 in UCEC (Pearson r = -0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CALML4 →	-0.590	-0.052	.004	.003	3	5
CCRCC	GALE →	-0.297	-0.037	.001	.003	3	5
CCRCC	PMM2 →	-0.304	-0.044	<.001	<.001	3	5
GBM	GDI1 →	+0.434	+0.087	<.001	<.001	3	5
GBM	NOP53 →	-0.306	-0.058	.006	.008	2	6
OV	MAP2_S833 →	+0.869	+0.079	.008	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021860 vs CALML4 — UCEC

Explore this scatter interactively →