Pyramidal neuron development

Across TCGA patient cohorts, RNA activity of the Pyramidal neuron development pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOX21, IL27RA, and LINC02361, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyramidal neuron development activity versus SOX21 in PDAC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SOX21 →	+0.844	+0.549	.003	.005	2	4
BRCA	IL27RA →	-0.634	-0.406	.007	.005	3	3
GBM	LINC02361 →	-0.420	-0.162	.002	.004	3	3
LSCC	RN7SL173P →	-0.328	-0.565	.005	.004	3	3
LUAD	TES →	-0.375	-0.623	.005	.002	3	2
LUAD	HLA-DRB5 →	-1.212	-0.798	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021860 vs SOX21 — PDAC

Explore this scatter interactively →