Pyramidal neuron differentiation

Across TCGA patient cohorts, RNA activity of the Pyramidal neuron differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SH3KBP1, TAP2, and CASP10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyramidal neuron differentiation activity versus SH3KBP1 in HNSC (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SH3KBP1 →	-0.280	-0.048	.001	.002	3	5
HNSC	TAP2 →	-0.685	-0.055	<.001	<.001	3	5
BRCA	CASP10 →	-0.568	-0.053	.001	<.001	3	5
HNSC	PSMB10 →	-0.424	-0.069	<.001	<.001	3	5
PDAC	AEBP1 →	+0.433	+0.029	<.001	.008	3	5
CCRCC	NOP53 →	-0.331	-0.034	.003	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021859 vs SH3KBP1 — HNSC

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