Pyramidal neuron differentiation

Across TCGA patient cohorts, RNA activity of the Pyramidal neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGAM4, SNX9, and STARD9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyramidal neuron differentiation activity versus PGAM4 in CCRCC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PGAM4 →	+0.176	+0.395	.003	.002	3	4
LSCC	SNX9 →	-0.247	-0.476	.001	.002	3	3
LSCC	STARD9 →	-0.398	-0.575	.003	.002	3	3
LSCC	NR2F2 →	-0.723	-0.799	<.001	<.001	3	3
LSCC	SOWAHB →	+0.496	+0.526	.007	<.001	3	3
LSCC	NDUFV2P1 →	-0.258	-0.649	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021859 vs PGAM4 — CCRCC

Explore this scatter interactively →