Hypothalamus cell migration

Across TCGA cell cohorts, RNA activity of the Hypothalamus cell migration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIPA1L3, ZNF705E, and KAT2A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SIPA1L3 grouped by Hypothalamus cell migration-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SIPA1L3 →	-1.430	-1.930	<.001	<.001	3	5
KIDNEY	ZNF705E →	+0.068	+0.974	.001	.007	3	5
KIDNEY	KAT2A →	+1.161	+1.505	.007	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	B4GALT7 →	-0.908	-1.350	.007	.002	3	4
BLOOD_Lymphoma	RREB1 →	+1.273	+1.850	.008	<.001	3	4
BONE	NPIPA8 →	+3.645	+1.897	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SIPA1L3 by Hypothalamus cell migration activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →