Hypothalamus development

Across TCGA patient cohorts, RNA activity of the Hypothalamus development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JAM2, ERG, and CAV2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hypothalamus development activity versus JAM2 in BRCA (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	JAM2 →	+0.523	+0.167	.006	<.001	3	5
BRCA	ERG →	+0.374	+0.126	.007	<.001	3	5
BRCA	CAV2 →	+0.585	+0.135	.002	<.001	3	4
BRCA	PPFIBP1 →	+0.548	+0.145	<.001	.003	3	4
BRCA	SPRY2 →	+0.726	+0.137	.004	.004	3	4
BRCA	DNAJB4 →	+0.527	+0.123	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021854 vs JAM2 — BRCA

Explore this scatter interactively →