Interneuron migration from the subpallium to the cortex

Across TCGA patient cohorts, RNA activity of the Interneuron migration from the subpallium to the cortex pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC4A4_S213, SLC4A4_S257, and F11R, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interneuron migration from the subpallium to the cortex activity versus SLC4A4_S213 in OV (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SLC4A4_S213 →	-2.011	-0.154	<.001	<.001	3	4
OV	SLC4A4_S257 →	-2.011	-0.154	<.001	<.001	3	4
HNSC	F11R →	+0.415	+0.180	.001	.006	3	4
GBM	TACC2_S2512 →	+0.328	+0.071	.006	.009	3	4
GBM	BORCS5_S75 →	+0.888	+0.119	<.001	<.001	3	4
GBM	ATG2B_S1743 →	+0.335	+0.084	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021830 vs SLC4A4_S213 — OV

Explore this scatter interactively →