Interneuron migration from the subpallium to the cortex

Across TCGA patient cohorts, RNA activity of the Interneuron migration from the subpallium to the cortex pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GARS1, SRSF5, and MXRA5, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interneuron migration from the subpallium to the cortex activity versus GARS1 in UCEC (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GARS1 →	+0.715	+0.283	.001	.007	3	3
GBM	SRSF5 →	-0.235	-0.667	.008	.002	3	2
GBM	MXRA5 →	+1.036	+0.577	.002	.002	3	2
GBM	RNU4-68P →	-0.566	-0.609	.006	.004	3	2
GBM	RNA5SP328 →	+0.712	+0.554	<.001	.002	3	2
GBM	ADGRF5-AS1 →	+0.486	+0.539	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021830 vs GARS1 — UCEC

Explore this scatter interactively →