Interneuron migration from the subpallium to the cortex

Across TCGA cell cohorts, RNA activity of the Interneuron migration from the subpallium to the cortex pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHST7, F8, and OR10G2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHST7 grouped by Interneuron migration from the subpallium to the cortex-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CHST7 →	-0.268	-1.101	.004	.005	3	4
KIDNEY	F8 →	+0.198	+1.818	.005	<.001	3	4
OVARY	OR10G2 →	-0.262	-1.487	.002	<.001	3	4
OESOPHAGUS	RALYL →	+0.145	+1.169	.001	.009	3	4
SOFT_TISSUE	SNRNP70 →	+0.306	+1.434	<.001	<.001	3	3
LUNG_SCLC	ZNF41 →	+0.160	+1.307	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHST7 by Interneuron migration from the subpallium to the cortex activity — SOFT_TISSUE

Explore this box plot interactively →