Substrate-independent telencephalic tangential migration

pathway activity — cross-omics
GO:0021826Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Substrate-independent telencephalic tangential migration pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNRIP1, CNN1, and LMOD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADCNRIP1 →+0.393+0.652.004.00334
CCRCCCNN1 →+1.532+0.754<.001<.00134
CCRCCLMOD1 →+1.102+0.642<.001<.00134
LUADJAM3 →+0.487+0.844.007<.00134
LUADSYNPO2 →+0.775+0.666.001<.00134
CCRCCDES →+1.758+0.634<.001.00234
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

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