Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration

Across TCGA patient cohorts, RNA activity of the Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1B_S2072, SET_S7, and DDX21_S89, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration activity versus MAP1B_S2072 in CCRCC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MAP1B_S2072 →	+0.810	+0.044	<.001	<.001	3	5
OV	SET_S7 →	-0.609	-0.062	.009	.001	3	5
LUAD	DDX21_S89 →	-0.850	-0.046	.001	.001	3	5
LUAD	EIF4B →	-0.241	-0.029	<.001	.006	3	5
OV	SRGAP2 →	+0.295	+0.060	<.001	<.001	3	4
GBM	CEP170 →	+0.339	+0.087	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021815 vs MAP1B_S2072 — CCRCC

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