Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration

Across TCGA pan-cancer cohorts, RNA activity of the Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and SCLC, show the opposite pattern, with higher activity associated with better survival.

KIRC, HNSC, and THCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	III,IV	0.265	0.595	.005	56	view →
HNSC	DFS	Median	IV	0.391	0.246	.001	49	view →
THCA	DFS	Median	IV	0.580	0.921	.001	48	view →
BLCA	OS	Quartile	All	0.515	0.741	.003	43	view →
SCLC	DFS	Median	II,III,IV	0.614	0.305	.003	40	view →
PAAD	OS	Tertile	All	0.271	0.524	.004	35	view →
ACC	DFS	Quartile	II,III,IV	0.110	0.660	<.001	31	view →
STAD	DFS	Quartile	II,III,IV	0.270	0.541	.005	26	view →
ESCA	OS	Median	IV	0.143	0.650	.004	24	view →
SKCM	OS	Median	II,III,IV	0.882	0.795	.004	21	view →
GBM	DFS	Quartile	All	0.416	0.151	.008	11	view →
UVM	DFS	Quartile	III,IV	0.161	0.864	.010	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0021815–KIRC (DFS)

Open the KIRC breakdown →