Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration

Across TCGA patient cohorts, RNA activity of the Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF2B1, STK4, and SCN5A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration activity versus EIF2B1 in UCEC (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EIF2B1 →	-0.559	-0.493	<.001	<.001	3	4
UCEC	STK4 →	-0.290	-0.252	.003	.009	3	4
UCEC	SCN5A →	+1.715	+0.462	<.001	<.001	3	4
CCRCC	ERG28 →	+0.259	+0.395	.002	.004	3	4
UCEC	HNRNPA3P1 →	+0.795	+0.360	.006	.002	3	3
UCEC	H4C1 →	-1.511	-0.371	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021815 vs EIF2B1 — UCEC

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