Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration

Across TCGA cell cohorts, RNA activity of the Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUSP18, PIGQ, and NDUFA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DUSP18 grouped by Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DUSP18 →	-0.772	-1.752	<.001	<.001	3	3
OESOPHAGUS	PIGQ →	-0.780	-1.752	<.001	<.001	3	3
BONE	NDUFA2 →	-0.535	-1.995	.002	.004	3	3
LUNG_NSCLC_LUSC	SNRK →	+0.754	+1.585	.005	.001	3	3
LUNG_NSCLC_LUSC	C1GALT1C1L →	-1.842	-1.785	.002	<.001	3	3
BREAST	RHCG →	+0.480	+0.676	.009	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DUSP18 by Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration activity — OESOPHAGUS

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