Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration

Across TCGA cell cohorts, RNA activity of the Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRGAP2, SRGAP2B, and SUN2, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration activity versus SRGAP2 in OESOPHAGUS (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SRGAP2 →	+1.572	+0.214	<.001	<.001	3	20
LUNG_NSCLC_LUSC	SRGAP2B →	+1.677	+0.153	<.001	.003	3	17
UPPER_AERODIGESTIVE_TRACT	SUN2 →	+1.480	+0.143	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	SIN3B →	+1.114	+0.145	.001	<.001	3	16
LIVER	SH3BP5L →	+1.058	+0.131	.002	<.001	3	16
LIVER	ZSWIM4 →	+1.932	+0.148	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021815 vs SRGAP2 — OESOPHAGUS

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