Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration

Across TCGA cell cohorts, RNA activity of the Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM20C, AIFM1, and CALD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration activity versus FAM20C in LUNG_SCLC (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FAM20C →	+2.721	+1.220	.001	<.001	3	7
BREAST	AIFM1 →	-0.748	-0.831	.004	.009	3	7
UPPER_AERODIGESTIVE_TRACT	CALD1 →	+1.850	+0.524	<.001	<.001	3	7
BLOOD_Lymphoma	SUN2 →	+1.139	+0.392	.008	.009	3	6
BONE	DNAJC12 →	-5.092	-1.983	<.001	<.001	3	6
SKIN	SH3BGRL3 →	+0.943	+1.137	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021815 vs FAM20C — LUNG_SCLC

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