Cell motility involved in cerebral cortex radial glia guided migration

Across TCGA cell cohorts, RNA activity of the Cell motility involved in cerebral cortex radial glia guided migration pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HEG1, SUN2, and CALD1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell motility involved in cerebral cortex radial glia guided migration activity versus HEG1 in BONE (Pearson r = 0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	HEG1 →	+3.347	+1.881	<.001	<.001	3	8
LUNG_NSCLC_LUSC	SUN2 →	+1.643	+2.110	.002	<.001	3	7
BREAST	CALD1 →	+3.993	+1.190	.005	.003	3	7
SKIN	HES6 →	-3.125	-1.819	<.001	<.001	3	7
LUNG_SCLC	AIFM1 →	-0.862	-1.119	<.001	.003	3	7
SKIN	ARHGAP23 →	+2.288	+1.386	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021814 vs HEG1 — BONE

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