Cerebral cortex radially oriented cell migration

Across TCGA patient cohorts, RNA activity of the Cerebral cortex radially oriented cell migration pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAPGEF2, RTN4, and SCN1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebral cortex radially oriented cell migration activity versus RAPGEF2 in GBM (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RAPGEF2 →	+0.274	+0.666	<.001	<.001	3	4
GBM	RTN4 →	+0.571	+1.055	<.001	<.001	3	4
CCRCC	SCN1B →	+0.596	+0.843	<.001	<.001	3	4
CCRCC	CRY2 →	+0.562	+0.597	.002	.009	3	4
CCRCC	HMCN1 →	+0.807	+0.736	.002	.001	3	4
UCEC	HK3 →	-0.899	-0.428	.008	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021799 vs RAPGEF2 — GBM

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