Cerebral cortex radially oriented cell migration

Across TCGA cell cohorts, RNA activity of the Cerebral cortex radially oriented cell migration pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RFC4, ABHD16B, and GDPD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RFC4 grouped by Cerebral cortex radially oriented cell migration-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RFC4 →	+0.703	+0.480	.007	.001	3	3
LUNG_SCLC	ABHD16B →	-0.753	-0.635	.005	.006	3	3
SOFT_TISSUE	GDPD1 →	+1.117	+1.301	.003	<.001	3	3
BREAST	LRPPRC →	+0.537	+0.598	.007	.003	2	4
OVARY	SLC36A4 →	-1.174	-0.881	.006	.006	3	3
KIDNEY	GOLPH3 →	+0.718	+1.436	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RFC4 by Cerebral cortex radially oriented cell migration activity — URINARY_TRACT

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