Cerebral cortex cell migration

Across TCGA patient cohorts, RNA activity of the Cerebral cortex cell migration pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIDINS220, UBR5, and TNKS2, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebral cortex cell migration activity versus KIDINS220 in CHOL (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	KIDINS220 →	+1.292	+0.055	<.001	<.001	3	33
UVM	UBR5 →	+1.280	+0.022	<.001	<.001	3	32
DLBC	TNKS2 →	+1.056	+0.036	<.001	<.001	3	32
ACC	CEP350 →	+0.934	+0.034	<.001	<.001	3	32
DLBC	REV1 →	+1.270	+0.045	<.001	<.001	3	32
CHOL	ABL2 →	+1.065	+0.052	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021795 vs KIDINS220 — CHOL

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