Thalamus development

Across TCGA patient cohorts, RNA activity of the Thalamus development pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CASK, PARD6B, and SP110_S380, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thalamus development activity versus CASK in COAD (Pearson r = -0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CASK →	+0.243	+0.039	<.001	<.001	3	5
UCEC	PARD6B →	+0.294	+0.075	.006	<.001	3	4
PDAC	SP110_S380 →	-0.531	-0.087	<.001	<.001	3	4
GBM	STK4_S410 →	-0.380	-0.071	<.001	<.001	3	4
PDAC	IFIH1 →	-0.421	-0.082	<.001	<.001	3	4
GBM	PINX1 →	-0.466	-0.073	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021794 vs CASK — COAD

Explore this scatter interactively →