Thalamus development

Across TCGA patient cohorts, RNA activity of the Thalamus development pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM6, KIF15, and HJURP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thalamus development activity versus MCM6 in LSCC (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MCM6 →	-0.588	-1.094	<.001	<.001	3	7
LSCC	KIF15 →	-0.585	-1.009	.001	<.001	3	6
LSCC	HJURP →	-0.771	-1.242	<.001	<.001	3	6
LSCC	CENPA →	-0.646	-0.675	<.001	.001	3	6
LSCC	CENPL →	-0.492	-0.832	.001	.006	3	6
OV	BUB1 →	-0.818	-0.038	.005	.003	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021794 vs MCM6 — LSCC

Explore this scatter interactively →