Thalamus development

Across TCGA cell cohorts, RNA activity of the Thalamus development pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP3K15, FGFR4, and RPL36AL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAP3K15 grouped by Thalamus development-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MAP3K15 →	+0.113	+0.109	.009	.004	3	5
BLOOD_Myeloma	FGFR4 →	+0.356	+0.155	.001	.009	3	4
KIDNEY	RPL36AL →	+0.209	+0.121	.006	.003	3	4
KIDNEY	CHMP4A →	-0.585	-0.163	.001	.004	3	4
LARGE_INTESTINE	CCT5 →	-0.220	-0.160	.001	.007	3	4
PANCREAS	BRCC3 →	+0.174	+0.157	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAP3K15 by Thalamus development activity — PANCREAS

Explore this box plot interactively →