Branchiomotor neuron axon guidance

Across TCGA patient cohorts, RNA activity of the Branchiomotor neuron axon guidance pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHYH, PLEKHA1, and MIR302A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Branchiomotor neuron axon guidance activity versus PHYH in BRCA (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PHYH →	-0.649	-1.080	<.001	<.001	3	4
UCEC	PLEKHA1 →	-0.568	-0.628	.001	.003	3	3
UCEC	MIR302A →	-1.152	-0.802	<.001	.001	3	3
UCEC	MYCBP2-AS1 →	+0.397	+0.915	<.001	<.001	3	3
UCEC	GDI2 →	-0.526	-0.736	.003	.002	2	4
UCEC	DHX32 →	-0.715	-0.688	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021785 vs PHYH — BRCA

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