Glial cell fate commitment

Across TCGA patient cohorts, RNA activity of the Glial cell fate commitment pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SOX9, HCLS1, and STK10, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glial cell fate commitment activity versus SOX9 in OV (Pearson r = 0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SOX9 →	+0.732	+0.139	.001	<.001	3	8
GBM	HCLS1 →	-0.507	-0.103	<.001	<.001	3	7
GBM	STK10 →	-0.344	-0.130	<.001	<.001	3	6
OV	TSN →	+0.476	+0.143	<.001	<.001	3	6
GBM	PSMB10 →	-0.388	-0.140	<.001	<.001	3	6
UCEC	SIN3A →	+0.139	+0.171	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021781 vs SOX9 — OV

Explore this scatter interactively →