Glial cell fate commitment

Across TCGA patient cohorts, RNA activity of the Glial cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFIB, GAB1, and TOP2A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glial cell fate commitment activity versus NFIB in GBM (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NFIB →	+0.960	+0.697	<.001	<.001	3	6
LUAD	GAB1 →	+0.569	+0.650	<.001	<.001	3	5
LUAD	TOP2A →	-1.147	-0.381	<.001	.009	3	5
GBM	KIDINS220 →	+0.261	+0.628	.004	.002	3	5
CCRCC	LONRF1 →	+0.631	+0.434	<.001	.002	3	5
GBM	GPBP1 →	+0.249	+0.412	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021781 vs NFIB — GBM

Explore this scatter interactively →