Amygdala development

pathway activity — cross-omics
GO:0021764Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Amygdala development pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CD34, COL14A1, and SYNPO2_T755, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CCRCCCD34 →-0.753-0.105<.001<.00136
UCECCOL14A1 →-0.752-0.143.002<.00136
COADSYNPO2_T755 →-0.521-0.064<.001<.00136
PDACTNXB →-0.657-0.086<.001<.00136
LUADHSPA12B →-0.346-0.101<.001<.00136
CCRCCPYGM →-0.428-0.111<.001<.00136
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration