Limbic system development

Across TCGA patient cohorts, RNA activity of the Limbic system development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PEX12, STKLD1, and KMT2E-AS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Limbic system development activity versus PEX12 in BRCA (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PEX12 →	+0.674	+0.181	<.001	.001	2	6
CCRCC	STKLD1 →	+0.243	+0.654	.001	.002	3	4
UCEC	KMT2E-AS1 →	+0.829	+0.187	.004	<.001	3	4
HNSC	C17orf75 →	+0.703	+0.283	<.001	.003	3	4
HNSC	KLHL12 →	+0.822	+0.268	<.001	.005	3	4
BRCA	RHOT1 →	+0.506	+0.177	.001	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021761 vs PEX12 — BRCA

Explore this scatter interactively →