Striatum development

Across TCGA patient cohorts, RNA activity of the Striatum development pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACKR1, TMEM88, and S1PR1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Striatum development activity versus ACKR1 in OV (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ACKR1 →	+1.418	+0.404	<.001	<.001	3	7
CCRCC	TMEM88 →	+1.031	+0.520	<.001	<.001	3	7
CCRCC	S1PR1 →	+0.853	+0.486	<.001	<.001	3	7
LUAD	NR4A3 →	+0.996	+0.471	<.001	.006	3	6
LSCC	C11orf96 →	+1.024	+0.469	<.001	<.001	3	6
CCRCC	KCNJ8 →	+0.831	+0.546	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021756 vs ACKR1 — OV

Explore this scatter interactively →