Striatum development

Across TCGA cell cohorts, RNA activity of the Striatum development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGBD1, VPS72, and TCAIM, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Striatum development activity versus PGBD1 in SOFT_TISSUE (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PGBD1 →	+0.766	+1.809	.007	<.001	3	3
BLOOD_Lymphoma	VPS72 →	-0.952	-1.212	<.001	<.001	3	3
OESOPHAGUS	TCAIM →	-0.865	-0.166	.005	.002	3	3
BLOOD_Leukemia	MYO1B →	-1.995	-0.696	.001	<.001	3	3
OESOPHAGUS	ZNHIT3 →	-1.234	-0.247	<.001	.006	3	3
LARGE_INTESTINE	H2AZ1 →	-0.922	-0.194	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021756 vs PGBD1 — SOFT_TISSUE

Explore this scatter interactively →