Cerebellar Purkinje cell layer formation

Across TCGA patient cohorts, RNA activity of the Cerebellar Purkinje cell layer formation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX21_S89, NOL10, and ARHGAP31_S1432, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebellar Purkinje cell layer formation activity versus DDX21_S89 in LUAD (Pearson r = 0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DDX21_S89 →	-0.936	-0.052	<.001	.002	3	9
BRCA	NOL10 →	-0.240	-0.035	.002	.002	3	6
PDAC	ARHGAP31_S1432 →	+0.699	+0.069	<.001	<.001	3	6
LUAD	DDX21_S121 →	-0.741	-0.060	<.001	<.001	2	7
PDAC	PAK2_S55 →	+1.141	+0.066	<.001	<.001	3	6
GBM	WDR43 →	-0.272	-0.079	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021694 vs DDX21_S89 — LUAD

Explore this scatter interactively →