Cerebellar Purkinje cell layer formation

Across TCGA pan-cancer cohorts, RNA activity of the Cerebellar Purkinje cell layer formation pathway differs between tumor and matched normal tissue in 12 of the 18 cancer types tested.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as BLCA and LUSC, show the opposite pattern, with lower activity in tumor tissue.

BLCA, LUSC, and LUAD show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
BLCA	Male	All	−0.088	<.001	8	view →
LUSC	Female	II,III,IV	−0.088	<.001	6	view →
LUAD	Female	II,III,IV	−0.066	<.001	6	view →
THCA	Female	All	−0.054	<.001	6	view →
LIHC	Female	II,III,IV	+0.046	<.001	6	view →
BRCA	All	II,III,IV	−0.036	<.001	6	view →
KIRC	Male	All	+0.034	<.001	5	view →
STAD	All	All	−0.070	.008	4	view →
UCEC	All	All	−0.062	<.001	4	view →
CHOL	All	All	+0.066	.002	3	view →
PRAD	All	All	−0.026	.004	2	view →
HNSC	All	All	−0.019	.043	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 12 lineages.

GO:0021694–BLCA

Open the BLCA breakdown →