Cerebellar Purkinje cell layer formation

Across TCGA cell cohorts, RNA activity of the Cerebellar Purkinje cell layer formation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FLNC, FBXO21, and ITPRID2, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebellar Purkinje cell layer formation activity versus FLNC in LUNG_SCLC (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FLNC →	+2.540	+0.591	.002	.004	2	1
LUNG_SCLC	FBXO21 →	-1.053	-0.591	.001	.004	2	1
LUNG_SCLC	ITPRID2 →	-1.830	-0.591	.003	.004	2	1
LUNG_SCLC	ZNF664 →	-0.966	-0.591	.006	.004	2	1
LUNG_SCLC	KRTAP5-8 →	-0.170	-0.591	.004	.004	2	1
LUNG_SCLC	CLCN3 →	+0.726	+0.591	.003	.004	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021694 vs FLNC — LUNG_SCLC

Explore this scatter interactively →