Cerebellar Purkinje cell layer formation

Across TCGA cell cohorts, RNA activity of the Cerebellar Purkinje cell layer formation pathway is significantly associated with the total protein of multiple features, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are JNK_pT183_Y185, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebellar Purkinje cell layer formation activity versus JNK_pT183_Y185 in LUNG_SCLC (Pearson r = 0.42).

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	JNK_pT183_Y185 →	+0.363	+0.590	.004	.010	3	1

Each partner links to its Q-omics profile. Showing the 1 strongest associations by consensus.

GO:0021694 vs JNK_pT183_Y185 — LUNG_SCLC

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