Cerebellar Purkinje cell layer morphogenesis

Across TCGA patient cohorts, RNA activity of the Cerebellar Purkinje cell layer morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UPP1, STK10, and EHD4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebellar Purkinje cell layer morphogenesis activity versus UPP1 in HNSC (Pearson r = -0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	UPP1 →	-0.755	-0.044	<.001	<.001	3	6
GBM	STK10 →	-0.326	-0.072	.003	.002	3	5
GBM	EHD4 →	-0.278	-0.054	<.001	<.001	3	5
CCRCC	PLIN3 →	-0.220	-0.032	.007	.002	3	5
HNSC	FADS2 →	+0.786	+0.070	<.001	<.001	3	5
COAD	CASP1 →	-0.451	-0.033	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021692 vs UPP1 — HNSC

Explore this scatter interactively →