Cerebellar Purkinje cell layer morphogenesis

Across TCGA patient cohorts, RNA activity of the Cerebellar Purkinje cell layer morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTBD8, MAGT1, and IKBIP, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebellar Purkinje cell layer morphogenesis activity versus BTBD8 in UCEC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BTBD8 →	+0.394	+0.174	.002	.002	3	3
BRCA	MAGT1 →	+0.488	+0.226	<.001	.002	3	3
GBM	IKBIP →	-0.448	-0.672	<.001	<.001	3	3
LUAD	IGHV3-30 →	-1.294	-0.149	<.001	.001	3	3
OV	IGKV1-39 →	-2.316	-0.451	<.001	.006	3	3
GBM	MAPK8IP1 →	+0.644	+0.662	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021692 vs BTBD8 — UCEC

Explore this scatter interactively →