Cerebellar granular layer morphogenesis

Across TCGA patient cohorts, RNA activity of the Cerebellar granular layer morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PROX1, PLCB1, and IRAIN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebellar granular layer morphogenesis activity versus PROX1 in LUAD (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PROX1 →	+0.937	+0.235	.001	.003	3	5
GBM	PLCB1 →	+0.662	+0.639	.004	<.001	3	4
PDAC	IRAIN →	-0.354	-0.687	.003	.002	3	3
COAD	RPS28P5 →	-0.490	-0.511	.002	.001	3	3
COAD	CAB39L →	+0.946	+0.564	.008	.003	3	3
UCEC	CDK17 →	+0.505	+0.237	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021683 vs PROX1 — LUAD

Explore this scatter interactively →