Cerebellar granular layer morphogenesis

Across TCGA cell cohorts, RNA activity of the Cerebellar granular layer morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP8A1, TMPRSS5, and YTHDC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP8A1 grouped by Cerebellar granular layer morphogenesis-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ATP8A1 →	+0.196	+0.812	<.001	.003	3	5
BREAST	TMPRSS5 →	-0.156	-1.021	.001	<.001	3	4
PANCREAS	YTHDC2 →	-0.156	-1.243	<.001	<.001	3	4
BLOOD_Lymphoma	DOC2A →	+0.225	+1.843	.004	.003	3	4
BLOOD_Leukemia	AGTR2 →	+0.136	+0.916	.003	.004	3	4
LUNG_NSCLC_LUAD	PSMB5 →	+0.414	+0.916	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP8A1 by Cerebellar granular layer morphogenesis activity — CNS

Explore this box plot interactively →