Cerebellar granular layer development

Across TCGA patient cohorts, RNA activity of the Cerebellar granular layer development pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RACGAP1_T342, TOP2A, and RIF1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebellar granular layer development activity versus RACGAP1_T342 in LUAD (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RACGAP1_T342 →	+0.666	+0.059	<.001	<.001	3	7
UCEC	TOP2A →	+0.820	+0.073	.003	.001	3	6
BRCA	RIF1 →	+0.434	+0.047	<.001	.001	3	6
LUAD	DLGAP4_T915 →	+0.600	+0.070	<.001	<.001	3	6
GBM	HCFC1 →	+0.186	+0.054	.001	.003	3	6
LUAD	HMGB3 →	+1.166	+0.081	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021681 vs RACGAP1_T342 — LUAD

Explore this scatter interactively →