Cerebellar granular layer development

Across TCGA cell cohorts, RNA activity of the Cerebellar granular layer development pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF14, KNDC1, and SERPINE2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KIF14 grouped by Cerebellar granular layer development-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	KIF14 →	-0.232	-1.237	.005	.007	3	8
UPPER_AERODIGESTIVE_TRACT	KNDC1 →	-0.378	-1.679	<.001	<.001	3	7
SKIN	SERPINE2 →	-0.244	-0.966	.002	.003	3	7
KIDNEY	L2HGDH →	-0.273	-1.325	.003	.003	3	6
LUNG_NSCLC_LUAD	WNT7A →	-0.220	-1.334	<.001	<.001	3	6
LIVER	NSUN2 →	-0.169	-1.784	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIF14 by Cerebellar granular layer development activity — KIDNEY

Explore this box plot interactively →