Cerebellar Purkinje cell layer development

Across TCGA patient cohorts, RNA activity of the Cerebellar Purkinje cell layer development pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL1A2, TUBA1A, and CAVIN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebellar Purkinje cell layer development activity versus COL1A2 in PDAC (Pearson r = -0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	COL1A2 →	-0.444	-0.307	.004	.006	3	3
PDAC	TUBA1A →	-0.412	-0.356	<.001	.001	3	3
PDAC	CAVIN1 →	-0.345	-0.314	.001	.005	3	3
BRCA	ISOC1 →	+0.641	+0.483	.006	.004	3	3
GBM	CYP2D6 →	+0.787	+0.784	<.001	<.001	3	3
GBM	CASC3 →	+0.340	+0.590	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021680 vs COL1A2 — PDAC

Explore this scatter interactively →